Stochastic NANOG fluctuations allow mouse embryonic stem cells to explore pluripotency

Heterogeneous expression of the transcription factor NANOG has been linked to the existence of various functional states in pluripotent stem cells. This heterogeneity seems to arise from fluctuations of Nanog expression in individual cells, but a thorough characterization of these fluctuations and t...

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Publicat a:Development
Autors principals: Abranches, Elsa, Guedes, Ana M. V., Moravec, Martin, Maamar, Hedia, Svoboda, Petr, Raj, Arjun, Henrique, Domingos
Format: Artigo
Idioma:Inglês
Publicat: The Company of Biologists 2014
Matèries:
Stem Cells and Regeneration
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6517831/
https://ncbi.nlm.nih.gov/pubmed/25005472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.108910
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