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Stochastic NANOG fluctuations allow mouse embryonic stem cells to explore pluripotency

Heterogeneous expression of the transcription factor NANOG has been linked to the existence of various functional states in pluripotent stem cells. This heterogeneity seems to arise from fluctuations of Nanog expression in individual cells, but a thorough characterization of these fluctuations and t...

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Detalhes bibliográficos
Publicado no:Development
Main Authors: Abranches, Elsa, Guedes, Ana M. V., Moravec, Martin, Maamar, Hedia, Svoboda, Petr, Raj, Arjun, Henrique, Domingos
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6517831/
https://ncbi.nlm.nih.gov/pubmed/25005472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.108910
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