Stochastic NANOG fluctuations allow mouse embryonic stem cells to explore pluripotency

Heterogeneous expression of the transcription factor NANOG has been linked to the existence of various functional states in pluripotent stem cells. This heterogeneity seems to arise from fluctuations of Nanog expression in individual cells, but a thorough characterization of these fluctuations and t...

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Vydáno v:Development
Hlavní autoři: Abranches, Elsa, Guedes, Ana M. V., Moravec, Martin, Maamar, Hedia, Svoboda, Petr, Raj, Arjun, Henrique, Domingos
Médium: Artigo
Jazyk:Inglês
Vydáno: The Company of Biologists 2014
Témata:
Stem Cells and Regeneration
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6517831/
https://ncbi.nlm.nih.gov/pubmed/25005472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.108910
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