Reduced FcRn-mediated transcytosis of IgG2 due to a missing Glycine in its lower hinge

Neonatal Fc-receptor (FcRn), the major histocompatibility complex (MHC) class I-like Fc-receptor, transports immunoglobuline G (IgG) across cell layers, extending IgG half-life in circulation and providing newborns with humoral immunity. IgG1 and IgG2 have similar half-lives, yet IgG2 displays lower...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Stapleton, Nigel M., Brinkhaus, Maximilian, Armour, Kathryn L., Bentlage, Arthur E. H., de Taeye, Steven W., Temming, A. Robin, Mok, Juk Yee, Brasser, Giso, Maas, Marielle, van Esch, Wim J. E., Clark, Mike R., Williamson, Lorna M., van der Schoot, C. Ellen, Vidarsson, Gestur
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2019
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6517591/
https://ncbi.nlm.nih.gov/pubmed/31089170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-40731-2
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