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Reduced FcRn-mediated transcytosis of IgG2 due to a missing Glycine in its lower hinge
Neonatal Fc-receptor (FcRn), the major histocompatibility complex (MHC) class I-like Fc-receptor, transports immunoglobuline G (IgG) across cell layers, extending IgG half-life in circulation and providing newborns with humoral immunity. IgG1 and IgG2 have similar half-lives, yet IgG2 displays lower...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6517591/ https://ncbi.nlm.nih.gov/pubmed/31089170 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-40731-2 |
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