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Reduced FcRn-mediated transcytosis of IgG2 due to a missing Glycine in its lower hinge

Neonatal Fc-receptor (FcRn), the major histocompatibility complex (MHC) class I-like Fc-receptor, transports immunoglobuline G (IgG) across cell layers, extending IgG half-life in circulation and providing newborns with humoral immunity. IgG1 and IgG2 have similar half-lives, yet IgG2 displays lower...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Stapleton, Nigel M., Brinkhaus, Maximilian, Armour, Kathryn L., Bentlage, Arthur E. H., de Taeye, Steven W., Temming, A. Robin, Mok, Juk Yee, Brasser, Giso, Maas, Marielle, van Esch, Wim J. E., Clark, Mike R., Williamson, Lorna M., van der Schoot, C. Ellen, Vidarsson, Gestur
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6517591/
https://ncbi.nlm.nih.gov/pubmed/31089170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-40731-2
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