Engineered antibody domains with significantly increased transcytosis and half-life in macaques mediated by FcRn

Engineered antibody domains (eAds) are promising candidate therapeutics but their half-life is relatively short partly due to weak or absent binding to the neonatal Fc receptor (FcRn). We developed a novel approach to increase the eAd binding to FcRn based on a combination of structure-based design,...

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Pubblicato in:MAbs
Autori principali: Ying, Tianlei, Wang, Yanping, Feng, Yang, Prabakaran, Ponraj, Gong, Rui, Wang, Lili, Crowder, Karalyne, Dimitrov, Dimiter S
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622838/
https://ncbi.nlm.nih.gov/pubmed/26179052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2015.1067353
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