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Engineered antibody domains with significantly increased transcytosis and half-life in macaques mediated by FcRn
Engineered antibody domains (eAds) are promising candidate therapeutics but their half-life is relatively short partly due to weak or absent binding to the neonatal Fc receptor (FcRn). We developed a novel approach to increase the eAd binding to FcRn based on a combination of structure-based design,...
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| Pubblicato in: | MAbs |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Taylor & Francis
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4622838/ https://ncbi.nlm.nih.gov/pubmed/26179052 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2015.1067353 |
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