Competition for FcRn-mediated transport gives rise to short half-life of human IgG3 and offers therapeutic potential

Human IgG3 displays the strongest effector functions of all IgG subclasses but has a short half-life for unresolved reasons. Here we show that IgG3 binds to IgG-salvage receptor (FcRn), but that FcRn-mediated transport and rescue of IgG3 is inhibited in the presence of IgG1 due to intracellular comp...

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Detalhes bibliográficos
Main Authors: Stapleton, Nigel M., Andersen, Jan Terje, Stemerding, Annette M., Bjarnarson, Stefania P., Verheul, Ruurd C., Gerritsen, Jacoline, Zhao, Yixian, Kleijer, Marion, Sandlie, Inger, de Haas, Masja, Jonsdottir, Ingileif, van der Schoot, C. Ellen, Vidarsson, Gestur
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3247843/
https://ncbi.nlm.nih.gov/pubmed/22186895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms1608
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