Two-Dimensional Separation Using High-pH and Low-pH Reversed Phase Liquid Chromatography for Top-down Proteomics

Advancements in chromatographic separation are critical to in-depth top-down proteomics of complex intact protein samples. Reversed-phase liquid chromatography is the most prevalent technique for top-down proteomics. However, in cases of high complexities and large dynamic ranges, 1D-RPLC may not pr...

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Vydáno v:Int J Mass Spectrom
Hlavní autoři: Wang, Zhe, Ma, Hongyan, Smith, Kenneth, Wu, Si
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6516780/
https://ncbi.nlm.nih.gov/pubmed/31097918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijms.2017.09.001
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