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Modular total synthesis and cell-based anticancer activity evaluation of ouabagenin and other cardiotonic steroids with varying degrees of oxygenation.

A Cu(II)-catalyzed diastereoselective Michael/aldol cascade approach is used to accomplish concise total syntheses of cardiotonic steroids with varying degrees of oxygenation including cardenolides ouabagenin, sarmentologenin, 19-hydroxysarmentogenin, and 5-epi-panogenin. These syntheses enabled the...

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Detaylı Bibliyografya
Yayımlandı:J Am Chem Soc
Asıl Yazarlar: Khatri, Hem Raj, Bhattarai, Bijay, Kaplan, Will, Li, Zhongzheng, Curtis Long, Marcus John, Aye, Yimon, Nagorny, Pavel
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6516474/
https://ncbi.nlm.nih.gov/pubmed/30802047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b12870
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