PKR knockout in the 5xFAD model of Alzheimer's disease reveals beneficial effects on spatial memory and brain lesions

Brain lesions in Alzheimer's disease (AD) include amyloid plaques made of Aβ peptides and neurofibrillary tangles composed of hyperphosphorylated tau protein with synaptic and neuronal loss and neuroinflammation. Aβ oligomers can trigger tau phosphorylation and neuronal alterations through acti...

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Bibliografische gegevens
Gepubliceerd in:Aging Cell
Hoofdauteurs: Tible, Marion, Mouton Liger, François, Schmitt, Julien, Giralt, Albert, Farid, Karim, Thomasseau, Sylvie, Gourmaud, Sarah, Paquet, Claire, Rondi Reig, Laure, Meurs, Eliane, Girault, Jean‐Antoine, Hugon, Jacques
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2019
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Original Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6516179/
https://ncbi.nlm.nih.gov/pubmed/30821420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12887
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