PKR knockout in the 5xFAD model of Alzheimer's disease reveals beneficial effects on spatial memory and brain lesions

Brain lesions in Alzheimer's disease (AD) include amyloid plaques made of Aβ peptides and neurofibrillary tangles composed of hyperphosphorylated tau protein with synaptic and neuronal loss and neuroinflammation. Aβ oligomers can trigger tau phosphorylation and neuronal alterations through acti...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Tible, Marion, Mouton Liger, François, Schmitt, Julien, Giralt, Albert, Farid, Karim, Thomasseau, Sylvie, Gourmaud, Sarah, Paquet, Claire, Rondi Reig, Laure, Meurs, Eliane, Girault, Jean‐Antoine, Hugon, Jacques
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6516179/
https://ncbi.nlm.nih.gov/pubmed/30821420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12887
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