Systemic clearance of p16(INK4a)‐positive senescent cells mitigates age‐associated intervertebral disc degeneration

RATIONALE: Age‐related changes in the intervertebral discs are the predominant contributors to back pain, a common physical and functional impairment experienced by older persons. Cellular senescence, a process wherein cells undergo growth arrest and chronically secrete numerous inflammatory molecul...

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Bibliografische gegevens
Gepubliceerd in:Aging Cell
Hoofdauteurs: Patil, Prashanti, Dong, Qing, Wang, Dong, Chang, Jianhui, Wiley, Christopher, Demaria, Marco, Lee, Joon, Kang, James, Niedernhofer, Laura J., Robbins, Paul D., Sowa, Gwendolyn, Campisi, Judith, Zhou, Daohong, Vo, Nam
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2019
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Original Papers
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6516165/
https://ncbi.nlm.nih.gov/pubmed/30900385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12927
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