IL‐1α cleavage by inflammatory caspases of the noncanonical inflammasome controls the senescence‐associated secretory phenotype

Interleukin‐1 alpha (IL‐1α) is a powerful cytokine that modulates immunity, and requires canonical cleavage by calpain for full activity. Mature IL‐1α is produced after inflammasome activation and during cell senescence, but the protease cleaving IL‐1α in these contexts is unknown. We show IL‐1α is...

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Publicat a:Aging Cell
Autors principals: Wiggins, Kimberley A., Parry, Aled J., Cassidy, Liam D., Humphry, Melanie, Webster, Steve J., Goodall, Jane C., Narita, Masashi, Clarke, Murray C. H.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2019
Matèries:
Original Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6516163/
https://ncbi.nlm.nih.gov/pubmed/30916891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12946
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