IL‐1α cleavage by inflammatory caspases of the noncanonical inflammasome controls the senescence‐associated secretory phenotype

Interleukin‐1 alpha (IL‐1α) is a powerful cytokine that modulates immunity, and requires canonical cleavage by calpain for full activity. Mature IL‐1α is produced after inflammasome activation and during cell senescence, but the protease cleaving IL‐1α in these contexts is unknown. We show IL‐1α is...

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Publicado en:Aging Cell
Autores principales: Wiggins, Kimberley A., Parry, Aled J., Cassidy, Liam D., Humphry, Melanie, Webster, Steve J., Goodall, Jane C., Narita, Masashi, Clarke, Murray C. H.
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2019
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Original Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6516163/
https://ncbi.nlm.nih.gov/pubmed/30916891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12946
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