IL‐1α cleavage by inflammatory caspases of the noncanonical inflammasome controls the senescence‐associated secretory phenotype

Interleukin‐1 alpha (IL‐1α) is a powerful cytokine that modulates immunity, and requires canonical cleavage by calpain for full activity. Mature IL‐1α is produced after inflammasome activation and during cell senescence, but the protease cleaving IL‐1α in these contexts is unknown. We show IL‐1α is...

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Bibliografiske detaljer
Udgivet i:Aging Cell
Main Authors: Wiggins, Kimberley A., Parry, Aled J., Cassidy, Liam D., Humphry, Melanie, Webster, Steve J., Goodall, Jane C., Narita, Masashi, Clarke, Murray C. H.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2019
Fag:
Original Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6516163/
https://ncbi.nlm.nih.gov/pubmed/30916891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12946
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