Chitinase 1 regulates pulmonary fibrosis by modulating TGF-β/SMAD7 pathway via TGFBRAP1 and FOXO3

TGF-β1 is a critical mediator of tissue fibrosis in health and disease whose effects are augmented by chitinase 1 (CHIT1). However, the mechanisms that CHIT1 uses to regulate TGF-β1–mediated fibrotic responses have not been defined. Here, we demonstrate that CHIT1 enhances TGF-β1–stimulated fibrotic...

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Detalhes bibliográficos
Publicado no:Life Sci Alliance
Main Authors: Lee, Chang-Min, He, Chuan-Hua, Park, Jin Wook, Lee, Jae Hyun, Kamle, Suchita, Ma, Bing, Akosman, Bedia, Cotez, Roberto, Chen, Emily, Zhou, Yang, Herzog, Erica L, Ryu, Changwan, Peng, Xueyan, Rosas, Ivan O, Poli, Sergio, Bostwick, Carol Feghali, Choi, Augustine M, Elias, Jack A, Lee, Chun Geun
Formato: Artigo
Idioma:Inglês
Publicado em: Life Science Alliance LLC 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6516052/
https://ncbi.nlm.nih.gov/pubmed/31085559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201900350
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