Chitinase 1 regulates pulmonary fibrosis by modulating TGF-β/SMAD7 pathway via TGFBRAP1 and FOXO3

TGF-β1 is a critical mediator of tissue fibrosis in health and disease whose effects are augmented by chitinase 1 (CHIT1). However, the mechanisms that CHIT1 uses to regulate TGF-β1–mediated fibrotic responses have not been defined. Here, we demonstrate that CHIT1 enhances TGF-β1–stimulated fibrotic...

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Publicat a:Life Sci Alliance
Autors principals: Lee, Chang-Min, He, Chuan-Hua, Park, Jin Wook, Lee, Jae Hyun, Kamle, Suchita, Ma, Bing, Akosman, Bedia, Cotez, Roberto, Chen, Emily, Zhou, Yang, Herzog, Erica L, Ryu, Changwan, Peng, Xueyan, Rosas, Ivan O, Poli, Sergio, Bostwick, Carol Feghali, Choi, Augustine M, Elias, Jack A, Lee, Chun Geun
Format: Artigo
Idioma:Inglês
Publicat: Life Science Alliance LLC 2019
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6516052/
https://ncbi.nlm.nih.gov/pubmed/31085559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201900350
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