Chitinase 1 regulates pulmonary fibrosis by modulating TGF-β/SMAD7 pathway via TGFBRAP1 and FOXO3

TGF-β1 is a critical mediator of tissue fibrosis in health and disease whose effects are augmented by chitinase 1 (CHIT1). However, the mechanisms that CHIT1 uses to regulate TGF-β1–mediated fibrotic responses have not been defined. Here, we demonstrate that CHIT1 enhances TGF-β1–stimulated fibrotic...

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Bibliografiske detaljer
Udgivet i:Life Sci Alliance
Main Authors: Lee, Chang-Min, He, Chuan-Hua, Park, Jin Wook, Lee, Jae Hyun, Kamle, Suchita, Ma, Bing, Akosman, Bedia, Cotez, Roberto, Chen, Emily, Zhou, Yang, Herzog, Erica L, Ryu, Changwan, Peng, Xueyan, Rosas, Ivan O, Poli, Sergio, Bostwick, Carol Feghali, Choi, Augustine M, Elias, Jack A, Lee, Chun Geun
Format: Artigo
Sprog:Inglês
Udgivet: Life Science Alliance LLC 2019
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6516052/
https://ncbi.nlm.nih.gov/pubmed/31085559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201900350
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