Chitinase 1 Is a Biomarker for and Therapeutic Target in Scleroderma-Associated Interstitial Lung Disease That Augments TGF-β1 Signaling

Interstitial lung disease (ILD) with pulmonary fibrosis is an important manifestation in systemic sclerosis (SSc, scleroderma) where it portends a poor prognosis. However, biomarkers that predict the development and or severity of SSc-ILD have not been validated, and the pathogenetic mechanisms that...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Lee, Chun Geun, Herzog, Erica L., Ahangari, Farida, Zhou, Yang, Gulati, Mridu, Lee, Chang-Min, Peng, Xueyan, Feghali-Bostwick, Carol, Jimenez, Sergio A., Varga, John, Elias, Jack A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4336775/
https://ncbi.nlm.nih.gov/pubmed/22826322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1201115
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