Role of Semaphorin 7a signaling in TGF-β1 induced lung fibrosis and scleroderma-related interstitial lung disease

OBJECTIVE: Semaphorin (Sema) 7a regulates TGF- β1 induced fibrosis. Using a murine model of pulmonary fibrosis in which an inducible, bioactive form of the human TGF- β1 gene is overexpressed in the lung, we tested the hypothesis that Sema-7a exerts its pro-fibrotic effects in part by promoting the...

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Main Authors: Gan, Ye, Reilkoff, Ronald, Peng, Xueyan, Russell, Thomas, Chen, Qingsheng, Mathai, Susan K., Homer, Robert, Gulati, Mridu, Siner, Jonathan, Elias, Jack, Bucala, Richard, Herzog, Erica
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3651701/
https://ncbi.nlm.nih.gov/pubmed/21484765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.30386
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