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Extracellular DNA, Neutrophil Extracellular Traps, and Inflammasome Activation in Severe Asthma

Rationale: Extracellular DNA (eDNA) and neutrophil extracellular traps (NETs) are implicated in multiple inflammatory diseases. NETs mediate inflammasome activation and IL-1β secretion from monocytes and cause airway epithelial cell injury, but the role of eDNA, NETs, and IL-1β in asthma is uncertai...

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Détails bibliographiques
Publié dans:Am J Respir Crit Care Med
Auteurs principaux: Lachowicz-Scroggins, Marrah E., Dunican, Eleanor M., Charbit, Annabelle R., Raymond, Wilfred, Looney, Mark R., Peters, Michael C., Gordon, Erin D., Woodruff, Prescott G., Lefrançais, Emma, Phillips, Brenda R., Mauger, David T., Comhair, Suzy A., Erzurum, Serpil C., Johansson, Mats W., Jarjour, Nizar N., Coverstone, Andrea M., Castro, Mario, Hastie, Annette T., Bleecker, Eugene R., Fajt, Merritt L., Wenzel, Sally E., Israel, Elliot, Levy, Bruce D.
Format: Artigo
Langue:Inglês
Publié: American Thoracic Society 2019
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6515873/
https://ncbi.nlm.nih.gov/pubmed/30888839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201810-1869OC
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