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Extracellular DNA, Neutrophil Extracellular Traps, and Inflammasome Activation in Severe Asthma

Rationale: Extracellular DNA (eDNA) and neutrophil extracellular traps (NETs) are implicated in multiple inflammatory diseases. NETs mediate inflammasome activation and IL-1β secretion from monocytes and cause airway epithelial cell injury, but the role of eDNA, NETs, and IL-1β in asthma is uncertai...

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Bibliografiske detaljer
Udgivet i:Am J Respir Crit Care Med
Main Authors: Lachowicz-Scroggins, Marrah E., Dunican, Eleanor M., Charbit, Annabelle R., Raymond, Wilfred, Looney, Mark R., Peters, Michael C., Gordon, Erin D., Woodruff, Prescott G., Lefrançais, Emma, Phillips, Brenda R., Mauger, David T., Comhair, Suzy A., Erzurum, Serpil C., Johansson, Mats W., Jarjour, Nizar N., Coverstone, Andrea M., Castro, Mario, Hastie, Annette T., Bleecker, Eugene R., Fajt, Merritt L., Wenzel, Sally E., Israel, Elliot, Levy, Bruce D.
Format: Artigo
Sprog:Inglês
Udgivet: American Thoracic Society 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6515873/
https://ncbi.nlm.nih.gov/pubmed/30888839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201810-1869OC
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