Extracellular DNA, Neutrophil Extracellular Traps, and Inflammasome Activation in Severe Asthma

Rationale: Extracellular DNA (eDNA) and neutrophil extracellular traps (NETs) are implicated in multiple inflammatory diseases. NETs mediate inflammasome activation and IL-1β secretion from monocytes and cause airway epithelial cell injury, but the role of eDNA, NETs, and IL-1β in asthma is uncertai...

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Detalhes bibliográficos
Publicado no:Am J Respir Crit Care Med
Main Authors: Lachowicz-Scroggins, Marrah E., Dunican, Eleanor M., Charbit, Annabelle R., Raymond, Wilfred, Looney, Mark R., Peters, Michael C., Gordon, Erin D., Woodruff, Prescott G., Lefrançais, Emma, Phillips, Brenda R., Mauger, David T., Comhair, Suzy A., Erzurum, Serpil C., Johansson, Mats W., Jarjour, Nizar N., Coverstone, Andrea M., Castro, Mario, Hastie, Annette T., Bleecker, Eugene R., Fajt, Merritt L., Wenzel, Sally E., Israel, Elliot, Levy, Bruce D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2019
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6515873/
https://ncbi.nlm.nih.gov/pubmed/30888839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201810-1869OC
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