Extracellular DNA, Neutrophil Extracellular Traps, and Inflammasome Activation in Severe Asthma

Rationale: Extracellular DNA (eDNA) and neutrophil extracellular traps (NETs) are implicated in multiple inflammatory diseases. NETs mediate inflammasome activation and IL-1β secretion from monocytes and cause airway epithelial cell injury, but the role of eDNA, NETs, and IL-1β in asthma is uncertai...

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Bibliografske podrobnosti
izdano v:Am J Respir Crit Care Med
Main Authors: Lachowicz-Scroggins, Marrah E., Dunican, Eleanor M., Charbit, Annabelle R., Raymond, Wilfred, Looney, Mark R., Peters, Michael C., Gordon, Erin D., Woodruff, Prescott G., Lefrançais, Emma, Phillips, Brenda R., Mauger, David T., Comhair, Suzy A., Erzurum, Serpil C., Johansson, Mats W., Jarjour, Nizar N., Coverstone, Andrea M., Castro, Mario, Hastie, Annette T., Bleecker, Eugene R., Fajt, Merritt L., Wenzel, Sally E., Israel, Elliot, Levy, Bruce D.
Format: Artigo
Jezik:Inglês
Izdano: American Thoracic Society 2019
Teme:
Original Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6515873/
https://ncbi.nlm.nih.gov/pubmed/30888839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201810-1869OC
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