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Refractory airway type 2 inflammation in a large subgroup of asthmatic patients treated with inhaled corticosteroids

BACKGROUND: Airway type 2 inflammation is usually corticosteroid sensitive, but the role of type 2 inflammation as a mechanism of asthma in patients receiving high-dose inhaled corticosteroids (ICSs) is uncertain. OBJECTIVE: We sought to determine whether airway type 2 inflammation persists in patie...

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Pubblicato in:J Allergy Clin Immunol
Autori principali: Peters, Michael C., Kerr, Sheena, Dunican, Eleanor M., Woodruff, Prescott G., Fajt, Merritt L., Levy, Bruce D., Israel, Elliot, Phillips, Brenda R., Mauger, David T., Comhair, Suzy A., Erzurum, Serpil C., Johansson, Mats W., Jarjour, Nizar N., Coverstone, Andrea M., Castro, Mario, Hastie, Annette T., Bleecker, Eugene R., Wenzel, Sally E., Fahy, John V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6128784/
https://ncbi.nlm.nih.gov/pubmed/29524537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2017.12.1009
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