An Investigation on Glucuronidation Metabolite Identification, Isozyme Contribution, and Species Differences of GL-V9 In Vitro and In Vivo

GL-V9 is a prominent derivative of wogonin with a wide therapeutic spectrum and potent anti-tumor activity. The metabolism characteristics of GL-V9 remain unclear. This study aimed to clarify the metabolic pathway of GL-V9 and investigate the generation of its glucuronidation metabolites in vitro an...

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Vydáno v:Molecules
Hlavní autoři: Xing, Han, Kong, Dexuan, Ning, Chen, Kong, Ying, Ren, Chang, Cheng, Yujie, Cai, Hui, Wang, Jubo, Zhao, Di, Li, Ning, Chen, Xijing, Li, Zhiyu, Lu, Yang
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6515479/
https://ncbi.nlm.nih.gov/pubmed/31013570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24081576
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