Regioselective Glucuronidation of Andrographolide and Its Major Derivatives: Metabolite Identification, Isozyme Contribution, and Species Differences

Andrographolide (AND) and two of its derivatives, deoxyandrographolide (DEO) and dehydroandrographolide (DEH), are widely used in clinical practice as anti-inflammatory agents. However, UDP-glucuronosyltransferase (UGT)-mediated phase II metabolism of these compounds is not fully understood. In this...

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Detalhes bibliográficos
Publicado no:AAPS J
Main Authors: Tian, Xiangge, Liang, Sicheng, Wang, Chao, Wu, Baojian, Ge, Guangbo, Deng, Sa, Liu, Kexin, Yang, Ling, Ma, Xiaochi
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4287282/
https://ncbi.nlm.nih.gov/pubmed/25204783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-014-9658-8
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