A reciprocal feedback between the PDZ binding kinase and androgen receptor drives prostate cancer

Elucidation of mechanisms underlying the increased androgen receptor (AR) activity and subsequent development of aggressive prostate cancer (PrCa) is pivotal in developing new therapies. Using a systems biology approach, we interrogated the AR-regulated proteome and identified PDZ binding kinase (PB...

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Veröffentlicht in:Oncogene
Hauptverfasser: Warren, Anne Y., Massie, Charlie E., Watt, Kate, Luko, Katarina, Orafidiya, Folake, Selth, Luke A., Mohammed, Hisham, Chohan, Brinder S., Menon, Suraj, Baridi, Ajoeb, Zhao, Wanfeng, Escriu, Carles, Pungsrinont, Thanakorn, D’Santos, Clive, Yang, Xiaoping, Taylor, Chris, Qureshi, Arham, Zecchini, Vincent R., Shaw, Greg L., Dehm, Scott M., Mills, Ian G., Carroll, Jason S., Tilley, Wayne D., McEwan, Iain J., Baniahmad, Aria, Neal, David E., Asim, Mohammad
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6514849/
https://ncbi.nlm.nih.gov/pubmed/30237440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0501-z
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