Choline Kinase Alpha as an Androgen Receptor Chaperone and Prostate Cancer Therapeutic Target

BACKGROUND: The androgen receptor (AR) is a major drug target in prostate cancer (PCa). We profiled the AR-regulated kinome to identify clinically relevant and druggable effectors of AR signaling. METHODS: Using genome-wide approaches, we interrogated all AR regulated kinases. Among these, choline k...

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Detalhes bibliográficos
Publicado no:J Natl Cancer Inst
Main Authors: Asim, Mohammad, Massie, Charles E., Orafidiya, Folake, Pértega-Gomes, Nelma, Warren, Anne Y., Esmaeili, Mohsen, Selth, Luke A., Zecchini, Heather I., Luko, Katarina, Qureshi, Arham, Baridi, Ajoeb, Menon, Suraj, Madhu, Basetti, Escriu, Carlos, Lyons, Scott, Vowler, Sarah L., Zecchini, Vincent R., Shaw, Greg, Hessenkemper, Wiebke, Russell, Roslin, Mohammed, Hisham, Stefanos, Niki, Lynch, Andy G., Grigorenko, Elena, D’Santos, Clive, Taylor, Chris, Lamb, Alastair, Sriranjan, Rouchelle, Yang, Jiali, Stark, Rory, Dehm, Scott M., Rennie, Paul S., Carroll, Jason S., Griffiths, John R., Tavaré, Simon, Mills, Ian G., McEwan, Iain J., Baniahmad, Aria, Tilley, Wayne D., Neal, David E.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4849803/
https://ncbi.nlm.nih.gov/pubmed/26657335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djv371
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