Pyruvate Dehydrogenase Kinase Is a Metabolic Checkpoint for Polarization of Macrophages to the M1 Phenotype

Metabolic reprogramming during macrophage polarization supports the effector functions of these cells in health and disease. Here, we demonstrate that pyruvate dehydrogenase kinase (PDK), which inhibits the pyruvate dehydrogenase-mediated conversion of cytosolic pyruvate to mitochondrial acetyl-CoA,...

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Pubblicato in:Front Immunol
Autori principali: Min, Byong-Keol, Park, Sungmi, Kang, Hyeon-Ji, Kim, Dong Wook, Ham, Hye Jin, Ha, Chae-Myeong, Choi, Byung-Jun, Lee, Jung Yi, Oh, Chang Joo, Yoo, Eun Kyung, Kim, Hui Eon, Kim, Byung-Gyu, Jeon, Jae-Han, Hyeon, Do Young, Hwang, Daehee, Kim, Yong-Hoon, Lee, Chul-Ho, Lee, Taeho, Kim, Jung-whan, Choi, Yeon-Kyung, Park, Keun-Gyu, Chawla, Ajay, Lee, Jongsoon, Harris, Robert A., Lee, In-Kyu
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2019
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6514528/
https://ncbi.nlm.nih.gov/pubmed/31134063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00944
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