Pyruvate Dehydrogenase Kinase Is a Metabolic Checkpoint for Polarization of Macrophages to the M1 Phenotype

Metabolic reprogramming during macrophage polarization supports the effector functions of these cells in health and disease. Here, we demonstrate that pyruvate dehydrogenase kinase (PDK), which inhibits the pyruvate dehydrogenase-mediated conversion of cytosolic pyruvate to mitochondrial acetyl-CoA,...

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Detalles Bibliográficos
Publicado en:Front Immunol
Main Authors: Min, Byong-Keol, Park, Sungmi, Kang, Hyeon-Ji, Kim, Dong Wook, Ham, Hye Jin, Ha, Chae-Myeong, Choi, Byung-Jun, Lee, Jung Yi, Oh, Chang Joo, Yoo, Eun Kyung, Kim, Hui Eon, Kim, Byung-Gyu, Jeon, Jae-Han, Hyeon, Do Young, Hwang, Daehee, Kim, Yong-Hoon, Lee, Chul-Ho, Lee, Taeho, Kim, Jung-whan, Choi, Yeon-Kyung, Park, Keun-Gyu, Chawla, Ajay, Lee, Jongsoon, Harris, Robert A., Lee, In-Kyu
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6514528/
https://ncbi.nlm.nih.gov/pubmed/31134063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00944
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