Pyruvate Dehydrogenase Kinase Is a Metabolic Checkpoint for Polarization of Macrophages to the M1 Phenotype

Metabolic reprogramming during macrophage polarization supports the effector functions of these cells in health and disease. Here, we demonstrate that pyruvate dehydrogenase kinase (PDK), which inhibits the pyruvate dehydrogenase-mediated conversion of cytosolic pyruvate to mitochondrial acetyl-CoA,...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Min, Byong-Keol, Park, Sungmi, Kang, Hyeon-Ji, Kim, Dong Wook, Ham, Hye Jin, Ha, Chae-Myeong, Choi, Byung-Jun, Lee, Jung Yi, Oh, Chang Joo, Yoo, Eun Kyung, Kim, Hui Eon, Kim, Byung-Gyu, Jeon, Jae-Han, Hyeon, Do Young, Hwang, Daehee, Kim, Yong-Hoon, Lee, Chul-Ho, Lee, Taeho, Kim, Jung-whan, Choi, Yeon-Kyung, Park, Keun-Gyu, Chawla, Ajay, Lee, Jongsoon, Harris, Robert A., Lee, In-Kyu
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6514528/
https://ncbi.nlm.nih.gov/pubmed/31134063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00944
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados