Pyruvate Dehydrogenase Kinase 4 Promotes Vascular Calcification via SMAD1/5/8 Phosphorylation

Vascular calcification, a pathologic response to defective calcium and phosphate homeostasis, is strongly associated with cardiovascular mortality and morbidity. In this study, we have observed that pyruvate dehydrogenase kinase 4 (PDK4) is upregulated and pyruvate dehydrogenase complex phosphorylat...

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Pubblicato in:Sci Rep
Autori principali: Lee, Sun Joo, Jeong, Ji Yun, Oh, Chang Joo, Park, Sungmi, Kim, Joon-Young, Kim, Han-Jong, Doo Kim, Nam, Choi, Young-Keun, Do, Ji-Yeon, Go, Younghoon, Ha, Chae-Myung, Choi, Je-Yong, Huh, Seung, Ho Jeoung, Nam, Lee, Ki-Up, Choi, Hueng-Sik, Wang, Yu, Park, Keun-Gyu, Harris, Robert A., Lee, In-Kyu
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4642318/
https://ncbi.nlm.nih.gov/pubmed/26560812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep16577
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