Novel tau fragments in cerebrospinal fluid: relation to tangle pathology and cognitive decline in Alzheimer’s disease

Tau is an axonal microtubule-binding protein. Tau pathology in brain and increased tau concentration in the cerebrospinal fluid (CSF) are hallmarks of Alzheimer’s disease (AD). Most of tau in CSF is present as fragments. We immunoprecipitated tau from CSF and identified several endogenous peptides e...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Acta Neuropathol
Egile Nagusiak: Cicognola, Claudia, Brinkmalm, Gunnar, Wahlgren, Jessica, Portelius, Erik, Gobom, Johan, Cullen, Nicholas C., Hansson, Oskar, Parnetti, Lucilla, Constantinescu, Radu, Wildsmith, Kristin, Chen, Hsu-Hsin, Beach, Thomas G., Lashley, Tammaryn, Zetterberg, Henrik, Blennow, Kaj, Höglund, Kina
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Springer Berlin Heidelberg 2018
Gaiak:
Original Paper
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6514201/
https://ncbi.nlm.nih.gov/pubmed/30547227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-018-1948-2
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