Novel tau fragments in cerebrospinal fluid: relation to tangle pathology and cognitive decline in Alzheimer’s disease

Tau is an axonal microtubule-binding protein. Tau pathology in brain and increased tau concentration in the cerebrospinal fluid (CSF) are hallmarks of Alzheimer’s disease (AD). Most of tau in CSF is present as fragments. We immunoprecipitated tau from CSF and identified several endogenous peptides e...

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Enregistré dans:
Détails bibliographiques
Publié dans:Acta Neuropathol
Auteurs principaux: Cicognola, Claudia, Brinkmalm, Gunnar, Wahlgren, Jessica, Portelius, Erik, Gobom, Johan, Cullen, Nicholas C., Hansson, Oskar, Parnetti, Lucilla, Constantinescu, Radu, Wildsmith, Kristin, Chen, Hsu-Hsin, Beach, Thomas G., Lashley, Tammaryn, Zetterberg, Henrik, Blennow, Kaj, Höglund, Kina
Format: Artigo
Langue:Inglês
Publié: Springer Berlin Heidelberg 2018
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Original Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6514201/
https://ncbi.nlm.nih.gov/pubmed/30547227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-018-1948-2
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