Novel tau fragments in cerebrospinal fluid: relation to tangle pathology and cognitive decline in Alzheimer’s disease

Tau is an axonal microtubule-binding protein. Tau pathology in brain and increased tau concentration in the cerebrospinal fluid (CSF) are hallmarks of Alzheimer’s disease (AD). Most of tau in CSF is present as fragments. We immunoprecipitated tau from CSF and identified several endogenous peptides e...

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Bibliografiska uppgifter
I publikationen:Acta Neuropathol
Huvudupphovsmän: Cicognola, Claudia, Brinkmalm, Gunnar, Wahlgren, Jessica, Portelius, Erik, Gobom, Johan, Cullen, Nicholas C., Hansson, Oskar, Parnetti, Lucilla, Constantinescu, Radu, Wildsmith, Kristin, Chen, Hsu-Hsin, Beach, Thomas G., Lashley, Tammaryn, Zetterberg, Henrik, Blennow, Kaj, Höglund, Kina
Materialtyp: Artigo
Språk:Inglês
Publicerad: Springer Berlin Heidelberg 2018
Ämnen:
Original Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6514201/
https://ncbi.nlm.nih.gov/pubmed/30547227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-018-1948-2
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