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Acutely elevated O-GlcNAcylation suppresses hippocampal activity by modulating both intrinsic and synaptic excitability factors

Post-translational modification (PTM) plays a critical role in increasing proteome complexity and diversifying protein functions. O-GlcNAc modification is a reversible, dynamic and highly abundant PTM catalyzed by a single pair of enzymes, O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA), regardless...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Hwang, Hongik, Rhim, Hyewhon
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6514166/
https://ncbi.nlm.nih.gov/pubmed/31086206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-43017-9
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