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Elevated O-GlcNAcylation induces an antidepressant-like phenotype and decreased inhibitory transmission in medial prefrontal cortex

Depression is a devastating mental disorder affected by multiple factors that can have genetic, environmental, or metabolic causes. Although previous studies have reported an association of dysregulated glucose metabolism with depression, its underlying mechanism remains elusive at the molecular lev...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Cho, Yoonjeong, Hwang, Hongik, Rahman, Md. Ataur, Chung, ChiHye, Rhim, Hyewhon
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7181662/
https://ncbi.nlm.nih.gov/pubmed/32332789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-63819-6
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