Rational design, cognition and neuropathology evaluation of QTC-4-MeOBnE in a streptozotocin-induced mouse model of sporadic Alzheimer’s disease

Alzheimer’s disease (AD) is a multifactorial pathology characterized by amyloid deposits, neurofibrillary formation, oxidative stress and cholinergic system dysfunction. In this sense, here we report the rational design of a multi-target directed ligand (MTDL) for AD based on virtual screening and b...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Fronza, Mariana G., Baldinotti, Rodolfo, Martins, Maria Clara, Goldani, Bruna, Dalberto, Bianca Thaís, Kremer, Frederico Schmitt, Begnini, Karine, Pinto, Luciano da Silva, Lenardão, Eder João, Seixas, Fabiana K., Collares, Tiago, Alves, Diego, Savegnago, Lucielli
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6513848/
https://ncbi.nlm.nih.gov/pubmed/31086208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-43532-9
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