Rational design, cognition and neuropathology evaluation of QTC-4-MeOBnE in a streptozotocin-induced mouse model of sporadic Alzheimer’s disease

Alzheimer’s disease (AD) is a multifactorial pathology characterized by amyloid deposits, neurofibrillary formation, oxidative stress and cholinergic system dysfunction. In this sense, here we report the rational design of a multi-target directed ligand (MTDL) for AD based on virtual screening and b...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Fronza, Mariana G., Baldinotti, Rodolfo, Martins, Maria Clara, Goldani, Bruna, Dalberto, Bianca Thaís, Kremer, Frederico Schmitt, Begnini, Karine, Pinto, Luciano da Silva, Lenardão, Eder João, Seixas, Fabiana K., Collares, Tiago, Alves, Diego, Savegnago, Lucielli
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6513848/
https://ncbi.nlm.nih.gov/pubmed/31086208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-43532-9
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