Rational design, cognition and neuropathology evaluation of QTC-4-MeOBnE in a streptozotocin-induced mouse model of sporadic Alzheimer’s disease

Alzheimer’s disease (AD) is a multifactorial pathology characterized by amyloid deposits, neurofibrillary formation, oxidative stress and cholinergic system dysfunction. In this sense, here we report the rational design of a multi-target directed ligand (MTDL) for AD based on virtual screening and b...

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Publicado en:Sci Rep
Main Authors: Fronza, Mariana G., Baldinotti, Rodolfo, Martins, Maria Clara, Goldani, Bruna, Dalberto, Bianca Thaís, Kremer, Frederico Schmitt, Begnini, Karine, Pinto, Luciano da Silva, Lenardão, Eder João, Seixas, Fabiana K., Collares, Tiago, Alves, Diego, Savegnago, Lucielli
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6513848/
https://ncbi.nlm.nih.gov/pubmed/31086208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-43532-9
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