BET Inhibitors Reduce Cell Size and Induce Reversible Cell Cycle Arrest in AML

Inhibitors of the bromodomain and extra-terminal domain family (BETi) offer a new approach to treating hematological malignancies, with leukemias containing MLL rearrangements being especially sensitive due to a reliance on the regulation of transcription elongation. We explored the mechanism of act...

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Gepubliceerd in:J Cell Biochem
Hoofdauteurs: Zhang, Susu, Zhao, Yue, Heaster, Tiffany M., Fischer, Melissa A., Stengel, Kristy R., Zhou, Xiaofan, Ramsey, Haley, Zhou, Ming-Ming, Savona, Michael R., Skala, Melissa C., Hiebert, Scott W.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6513713/
https://ncbi.nlm.nih.gov/pubmed/30417424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.28005
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