Nascent transcript and single-cell RNA-seq analysis defines the mechanism of action of the LSD1 inhibitor INCB059872 in myeloid leukemia

Drugs targeting chromatin-modifying enzymes have entered clinical trials for myeloid malignancies, including INCB059872, a selective irreversible inhibitor of Lysine-Specific Demethylase 1 (LSD1). While initial studies of LSD1 inhibitors suggested these compounds may be used to induce differentiatio...

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Gepubliceerd in:Gene
Hoofdauteurs: Johnston, Gretchen, Ramsey, Haley, Liu, Qi, Wang, Jing, Stengel, Kristy R., Sampathi, Shilpa, Acharya, Pankaj, Arrate, Maria, Stubbs, Matthew C., Burn, Timothy, Savona, Michael R., Hiebert, Scott W.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7401316/
https://ncbi.nlm.nih.gov/pubmed/32422235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gene.2020.144758
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