Nascent transcript and single-cell RNA-seq analysis defines the mechanism of action of the LSD1 inhibitor INCB059872 in myeloid leukemia

Drugs targeting chromatin-modifying enzymes have entered clinical trials for myeloid malignancies, including INCB059872, a selective irreversible inhibitor of Lysine-Specific Demethylase 1 (LSD1). While initial studies of LSD1 inhibitors suggested these compounds may be used to induce differentiatio...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Gene
Main Authors: Johnston, Gretchen, Ramsey, Haley, Liu, Qi, Wang, Jing, Stengel, Kristy R., Sampathi, Shilpa, Acharya, Pankaj, Arrate, Maria, Stubbs, Matthew C., Burn, Timothy, Savona, Michael R., Hiebert, Scott W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7401316/
https://ncbi.nlm.nih.gov/pubmed/32422235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gene.2020.144758
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados