High Resolution Mapping of RNA Polymerases Identifies Mechanisms of Sensitivity and Resistance to BET Inhibitors in t(8;21) AML

Bromodomain and extra-terminal domain (BET) family inhibitors offer an approach to treating hematological malignancies. We used precision nuclear run-on transcription sequencing (PRO-seq) to create high-resolution maps of active RNA polymerases across the genome in t(8;21) acute myeloid leukemia (AM...

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Udgivet i:Cell Rep
Main Authors: Zhao, Yue, Liu, Qi, Acharya, Pankaj, Stengel, Kristy R., Sheng, Quanhu, Zhou, Xiaofan, Kwak, Hojoong, Fischer, Melissa A., Bradner, James E., Strickland, Stephen A., Mohan, Sanjay R., Savona, Michael R., Venters, Bryan J., Zhou, Ming-Ming, Lis, John T., Hiebert, Scott W.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4996374/
https://ncbi.nlm.nih.gov/pubmed/27498870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.07.032
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