Covalent labeling and mass spectrometry reveal subtle higher order structural changes for antibody therapeutics

Monoclonal antibodies are among the fastest growing therapeutics in the pharmaceutical industry. Detecting higher-order structure changes of antibodies upon storage or mishandling, however, is a challenging problem. In this study, we describe the use of diethylpyrocarbonate (DEPC)-based covalent lab...

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Bibliographic Details
Published in:MAbs
Main Authors: Limpikirati, Patanachai, Hale, John E., Hazelbaker, Mark, Huang, Yongbo, Jia, Zhiguang, Yazdani, Mahdieh, Graban, Eric M., Vaughan, Robert C., Vachet, Richard W.
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6512938/
https://ncbi.nlm.nih.gov/pubmed/30636503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2019.1565748
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