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Structural characterization of monoclonal antibodies targeting C-terminal Ser(404) region of phosphorylated tau protein

Targeting tau with immunotherapies is currently the most common approach taken in clinical trials of patients with Alzheimer’s disease. The most prominent pathological feature of tau is its hyperphosphorylation, which may cause the protein to aggregate into toxic assemblies that collectively lead to...

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Bibliografiske detaljer
Udgivet i:MAbs
Main Authors: Chukwu, Jessica E., Congdon, Erin E., Sigurdsson, Einar M., Kong, Xiang-Peng
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6512906/
https://ncbi.nlm.nih.gov/pubmed/30794086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2019.1574530
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