Increasing Cytosine Base Editing Scope and Efficiency With Engineered Cas9-PmCDA1 Fusions and the Modified sgRNA in Rice

Base editors that do not require double-stranded DNA cleavage or homology-directed repair enable higher efficiency and cleaner substitution of targeted single nucleotides in genomic DNA than conventional approaches. However, their broad applications are limited within the editing window of several b...

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Foilsithe in:Front Genet
Main Authors: Wu, Ying, Xu, Wen, Wang, Feipeng, Zhao, Si, Feng, Feng, Song, Jinling, Zhang, Chengwei, Yang, Jinxiao
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2019
Ábhair:
Genetics
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6512751/
https://ncbi.nlm.nih.gov/pubmed/31134125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2019.00379
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