Increasing Cytosine Base Editing Scope and Efficiency With Engineered Cas9-PmCDA1 Fusions and the Modified sgRNA in Rice

Base editors that do not require double-stranded DNA cleavage or homology-directed repair enable higher efficiency and cleaner substitution of targeted single nucleotides in genomic DNA than conventional approaches. However, their broad applications are limited within the editing window of several b...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Front Genet
Prif Awduron: Wu, Ying, Xu, Wen, Wang, Feipeng, Zhao, Si, Feng, Feng, Song, Jinling, Zhang, Chengwei, Yang, Jinxiao
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2019
Pynciau:
Genetics
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6512751/
https://ncbi.nlm.nih.gov/pubmed/31134125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2019.00379
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