Increasing Cytosine Base Editing Scope and Efficiency With Engineered Cas9-PmCDA1 Fusions and the Modified sgRNA in Rice

Base editors that do not require double-stranded DNA cleavage or homology-directed repair enable higher efficiency and cleaner substitution of targeted single nucleotides in genomic DNA than conventional approaches. However, their broad applications are limited within the editing window of several b...

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Vydáno v:Front Genet
Hlavní autoři: Wu, Ying, Xu, Wen, Wang, Feipeng, Zhao, Si, Feng, Feng, Song, Jinling, Zhang, Chengwei, Yang, Jinxiao
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Genetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6512751/
https://ncbi.nlm.nih.gov/pubmed/31134125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2019.00379
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