Microbiotas from Humans with Inflammatory Bowel Disease Alter the Balance of Gut Th17 and RORγt(+) Regulatory T Cells and Exacerbate Colitis in Mice

Microbiota are thought to influence the development and progression of inflammatory bowel disease (IBD), but determining generalizable effects of microbiota on IBD etiology requires larger-scale functional analyses. We colonized germ-free mice with intestinal microbiotas from 30 healthy and IBD dono...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Britton, Graham J., Contijoch, Eduardo J., Mogno, Ilaria, Vennaro, Olivia H., Llewellyn, Sean R., Ng, Ruby, Li, Zhihua, Mortha, Arthur, Merad, Miriam, Das, Anuk, Gevers, Dirk, McGovern, Dermot P.B., Singh, Namita, Braun, Jonathan, Jacobs, Jonathan P., Clemente, Jose C., Grinspan, Ari, Sands, Bruce E., Colombel, Jean-Frederic, Dubinsky, Marla C., Faith, Jeremiah J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6512335/
https://ncbi.nlm.nih.gov/pubmed/30650377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2018.12.015
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