Defined microbiota transplant restores Th17/RORγt(+) regulatory T cell balance in mice colonized with inflammatory bowel disease microbiotas

The building evidence for the contribution of microbiota to human disease has spurred an effort to develop therapies that target the gut microbiota. This is particularly evident in inflammatory bowel diseases (IBDs), where clinical trials of fecal microbiota transplantation have shown some efficacy....

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Britton, Graham J., Contijoch, Eduardo J., Spindler, Matthew P., Aggarwala, Varun, Dogan, Belgin, Bongers, Gerold, San Mateo, Lani, Baltus, Andrew, Das, Anuk, Gevers, Dirk, Borody, Thomas J., Kaakoush, Nadeem O., Kamm, Michael A., Mitchell, Hazel, Paramsothy, Sudarshan, Clemente, Jose C., Colombel, Jean-Frederic, Simpson, Kenneth W., Dubinsky, Marla C., Grinspan, Ari, Faith, Jeremiah J.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2020
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7474624/
https://ncbi.nlm.nih.gov/pubmed/32817490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1922189117
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