Defective Renal Angiotensin III and AT(2) Receptor Signaling in Prehypertensive Spontaneously Hypertensive Rats

BACKGROUND: Previous studies demonstrated that angiotensin (Ang) III, not Ang II, is the predominant endogenous agonist for Ang type‐2 receptor (AT (2)R)‐induced natriuresis in normal rats, and that hypertensive 12‐week‐old spontaneously hypertensive rats (SHR) lack natriuretic responses to Ang III....

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Veröffentlicht in:J Am Heart Assoc
Hauptverfasser: Kemp, Brandon A., Howell, Nancy L., Keller, Susanna R., Gildea, John J., Shao, Weijian, Navar, Luis Gabriel, Carey, Robert M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2019
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6512109/
https://ncbi.nlm.nih.gov/pubmed/31039659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.119.012016
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