Defective Renal Angiotensin III and AT(2) Receptor Signaling in Prehypertensive Spontaneously Hypertensive Rats

BACKGROUND: Previous studies demonstrated that angiotensin (Ang) III, not Ang II, is the predominant endogenous agonist for Ang type‐2 receptor (AT (2)R)‐induced natriuresis in normal rats, and that hypertensive 12‐week‐old spontaneously hypertensive rats (SHR) lack natriuretic responses to Ang III....

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Publicado en:J Am Heart Assoc
Autores principales: Kemp, Brandon A., Howell, Nancy L., Keller, Susanna R., Gildea, John J., Shao, Weijian, Navar, Luis Gabriel, Carey, Robert M.
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2019
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Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6512109/
https://ncbi.nlm.nih.gov/pubmed/31039659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.119.012016
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