Defective Renal Angiotensin III and AT(2) Receptor Signaling in Prehypertensive Spontaneously Hypertensive Rats

BACKGROUND: Previous studies demonstrated that angiotensin (Ang) III, not Ang II, is the predominant endogenous agonist for Ang type‐2 receptor (AT (2)R)‐induced natriuresis in normal rats, and that hypertensive 12‐week‐old spontaneously hypertensive rats (SHR) lack natriuretic responses to Ang III....

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Bibliographic Details
Published in:J Am Heart Assoc
Main Authors: Kemp, Brandon A., Howell, Nancy L., Keller, Susanna R., Gildea, John J., Shao, Weijian, Navar, Luis Gabriel, Carey, Robert M.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2019
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6512109/
https://ncbi.nlm.nih.gov/pubmed/31039659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.119.012016
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