Interactions of p53 with poly(ADP-ribose) and DNA induce distinct changes in protein structure as revealed by ATR-FTIR spectroscopy

Due to multiple domains and in part intrinsically disordered regions, structural analyses of p53 remain a challenging task, particularly in complex with DNA and other macromolecules. Here, we applied a novel attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopic approach to...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Krüger, Annika, Stier, Anna, Fischbach, Arthur, Bürkle, Alexander, Hauser, Karin, Mangerich, Aswin
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Structural Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6511852/
https://ncbi.nlm.nih.gov/pubmed/30892621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz175
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