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Overlooked roles of DNA damage and maternal age in generating human germline mutations
The textbook view that most germline mutations in mammals arise from replication errors is indirectly supported by the fact that there are both more mutations and more cell divisions in the male than in the female germline. When analyzing large de novo mutation datasets in humans, we find multiple l...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6511033/ https://ncbi.nlm.nih.gov/pubmed/31019089 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1901259116 |
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