A carregar...

Large, three-generation human families reveal post-zygotic mosaicism and variability in germline mutation accumulation

The number of de novo mutations (DNMs) found in an offspring's genome increases with both paternal and maternal age. But does the rate of mutation accumulation in human gametes differ across families? Using sequencing data from 33 large, three-generation CEPH families, we observed significant v...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:eLife
Main Authors: Sasani, Thomas A, Pedersen, Brent S, Gao, Ziyue, Baird, Lisa, Przeworski, Molly, Jorde, Lynn B, Quinlan, Aaron R
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6759356/
https://ncbi.nlm.nih.gov/pubmed/31549960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.46922
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!